Amoebic Liver Abscess in Gerbils Gal-Inhibitable Lectin Vaccine against Entamoeba histolytica Adjuvant with an CpG-Oligodeoxynucleotide Is a Potent
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CpG-oligodeoxynucleotide is a potent adjuvant with an Entamoeba histolytica Gal-inhibitable lectin vaccine against amoebic liver abscess in gerbils.
The protozoan parasite Entamoeba histolytica causes invasive amoebiasis characterized by amoebic dysentery and liver abscesses (ALA). The E. histolytica galactose/N-acetyl-D-galactosamine-inhibitable lectin (Gal-lectin), an immunogenic surface molecule involved in colonization and invasion, is a promising vaccine candidate against amoebiasis. Gal-lectin is known to induce Th1 cytokines in macro...
متن کاملActivity of Picroliv Isolated from Picrorhiza kurrooa against Thioacetamide and Entamoeba histolytica Induced Liver Damage
Picroliv, an iridoid glycoside mixture, isolated from root and rhizome of Picrorhiza kurrooa known to possess significant hepatoprotective activity. Present study demonstrated the hepatoprotective potential of picroliv against thioacetamide and Entamoeba histolytica induced hepatic damage in rats, mastomys, and gerbils. Significant increase in the serum levels of hapatospecific markers was foun...
متن کاملProtection of gerbils from amebic liver abscess by immunization with the galactose-specific adherence lectin of Entamoeba histolytica.
No protective antigens from Entamoeba histolytica have been previously defined. We tested the ability of the galactose-specific adherence lectin of E. histolytica to elicit a protective immune response in conjunction with Freund's incomplete and complete adjuvants. The gerbil (Meriones unguiculatus) model of an experimental amebic liver abscess was used. Gerbils were immunized intraperitoneally...
متن کاملTrophozoites of Entamoeba histolytica epigenetically silenced in several genes are virulence-attenuated.
The human intestinal parasite Entamoeba histolytica causes amoebic colitis and amoebic liver abscesses. Three classes of amoebic molecules have been identified as the major virulence factors, the Gal/GalNAc inhibitable lectin that mediates adherence to mammalian cells, the amoebapores which cause the formation of membrane ion channels in the target cells and the cysteine proteinases which degra...
متن کاملProtective activity of picroliv on hepatic amoebiasis associated with carbon tetrachloride toxicity.
BACKGROUND AND OBJECTIVE Picroliv, isolated from the root and rhizome of Picrorhiza kurroa, is known to have significant hepatoprotective activity. Its effects against Entamoeba histolytica induced liver damage are not studied. This study aims to evaluate the hepatoprotective action of picroliv against the hepatotoxic changes induced by carbon tetrachloride (CCl(4)) and E. histolytica infection...
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